The match is consistently intense and fiercely competitive, making it one of the most eagerly anticipated fixtures in the Premier League schedule. The match officials can expect a challenging afternoon ahead.
But as Arsenal manager Mikel Arteta welcomes back his international players and prepares for the clash, he may not be best pleased with the refereeing appointment.
The Premier League have appointed Jarred Gillett for the match, with the Australian a familiar figure for the Gunners, with this already being his second Arsenal match of the season.
Gillett has overseen a number of controversial incidents when taking charge of Arsenal matches, including the season-opening match against Wolves, where he declined to send off Yerson Mosquera for grabbing Kai Havertz around the throat.
VIDEO Why Lee Carsley Might Fix England
Arsenal fans were left dumbfounded when Gillett did not take any action against the Wolves and then the VAR did not intervene. Mosquera then tussled with Gabriel Jesus, grabbing the Brazilian on the posterior, which led to Jesus being booked for his reaction.
Get FourFourTwo Newsletter
The best features, fun and footballing quizzes, straight to your inbox every week.
Contact me with news and offers from other Future brandsReceive email from us on behalf of our trusted partners or sponsorsBy submitting your information you agree to the Terms & Conditions and Privacy Policy and are aged 16 or over.
Last season saw Gillett disallow a last-minute Havertz goal against Aston Villa, with the Gunners claiming that the referee did not have a clear view of the incident.
Arsenal fans have been stewing over another refereeing decision during the international break, after Chris Kavanagh controversially sent off Declan Rice against Brighton last time out.
Rice will miss the north London derby through suspension, with skipper Martin Odegaard also set to miss out after suffering an injury on international duty with Norway, while summer signing Mikel Merino is still sidelined with a shoulder injury that he suffered in his first training session with the club.
More Arsenal stories
Arsenal could MOVE Bukayo Saka - in response to new crisis
Champions League Supercomputer predicts Premier League glory after titanic all-English clash
Arsenal preparing big contract for star forward: report